[Dec 19, 2025] ABMM Test Prep Training Practice Exam Questions Practice Tests [Q79-Q96]

Q79. A clinical microbiology laboratory is implementing a new multiplex nucleic acid amplification test (NAAT) for the detection of respiratory viral pathogens. To ensure the quantitative accuracy of the assay, it is essential to include:

Q80. A clinical microbiology laboratory is implementing a new MALDI-TOF mass spectrometry system for bacterial identification. For accurate identification, the system relies on comparing the protein profile of an unknown isolate to:

Q81. A microbiology laboratory is investigating a possible outbreak of Salmonella infection. Serological testing of patient isolates reveals they all possess the same O antigen but different H antigens. This suggests:

Q82. A clinical microbiology laboratory is implementing a new laboratory information system (LIS). A critical step in the validation process is ensuring the accurate and reliable transfer of data, including patient demographics, test orders, and results. This aspect of validation primarily focuses on:

Q83. A patient with a history of recurrent urinary tract infections caused by Escherichia coli develops a new infection. The urine isolate is resistant to trimethoprim-sulfamethoxazole. The MOST common mechanism of resistance to this antibiotic combination in E. coli involves:

Q84. The direct fluorescent antibody (DFA) test is commonly used for the rapid detection of which respiratory pathogen directly from nasopharyngeal specimens?

Q85. A clinical microbiology laboratory is using CRISPR-based technology for rapid and sensitive detection of specific bacterial DNA sequences directly from patient samples. This method relies on the ability of the Cas enzyme to:

Q86. A patient returning from a mission trip to Africa presents with fever, headache, and a characteristic relapsing pattern of symptoms. Peripheral blood smear reveals the presence of extracellular flagellated protozoa. The MOST likely diagnosis is African trypanosomiasis caused by:

Q87. A microbiology laboratory is asked to identify the causative agent of a fungal keratitis. Microscopic examination of corneal scrapings reveals broad, aseptate hyphae with right-angle branching. The MOST likely genus is:

Q88. Caspofungin, micafungin, and anidulafungin belong to the echinocandin class of antifungal agents. Their primary mechanism of action involves the non-competitive inhibition of:

Q89. The erm gene in Staphylococcus aureus confers resistance to which class(es) of antibiotics via modification of the ribosomal target site?

Q90. A microbiology laboratory is investigating an outbreak of bloodstream infections in a neonatal intensive care unit. Isolates of Staphylococcus epidermidis from multiple infants show indistinguishable banding patterns by pulsed-field gel electrophoresis (PFGE). This finding MOST strongly suggests:

Q91. A clinical microbiology laboratory is performing antimicrobial susceptibility testing on a Streptococcus pneumoniae isolate using broth microdilution. The lowest concentration of antibiotic that inhibits visible growth of the organism is reported as the:

Q92. A microbiology laboratory receives a sample of cerebrospinal fluid from a patient with suspected bacterial meningitis. The Gram stain shows Gram-positive diplococci. Culture on blood agar shows alpha-hemolytic colonies that are bile soluble and optochin-sensitive. The MOST likely organism is:

Q93. A microbiology laboratory is performing antimicrobial susceptibility testing using the Kirby-Bauer disk diffusion method. A bacterial isolate shows no zone of inhibition around a specific antibiotic disk. This result could be due to:

Q94. Metagenomic analysis of a bronchoalveolar lavage (BAL) sample from a patient with severe pneumonia reveals a complex microbial community with a high abundance of both bacterial and fungal sequences. This approach is particularly useful in identifying:

Q95. Histopathological examination of lung tissue from an immunocompromised patient reveals large (8-15 µm), spherical yeast cells with thick, refractile walls and characteristic single, broad-based budding. These findings are most suggestive of infection with:

Q96. A patient with a history of neutropenia develops a severe sinus infection. Tissue biopsy reveals broad, ribbon- like, non-septate hyphae with right-angle branching. The MOST likely causative organism belongs to the order: